Author: NY TIMES

The maker of the newest treatment approved for amyotrophic lateral sclerosis said Thursday that it would withdraw the drug from the market because a large clinical trial did not produce evidence that the treatment worked.The company, Amylyx Pharmaceuticals, said in a statement that it had started the process of withdrawing the drug in the United States, where it is called Relyvrio, and in Canada, where it is called Albrioza. As of Thursday, no new patients will be able to start the drug, while current patients who wish to continue taking the medication can be transitioned to a free drug program,…

The chorus master at the Metropolitan Opera has one of the company’s most demanding jobs. There are singers to corral, notes to correct and centuries-old scores to pore over.Donald Palumbo, who brought the chorus to new heights during his 17-year tenure as chorus master, announced last fall that he would step down in June. And on Wednesday, the Met announced his successor: the German conductor Tilman Michael, who has served as chorus master of the Frankfurt Opera for the past decade.Michael, 49, who will join the company at the start of the 2024-25 season in the role of chorus director,…

President Biden said he was “outraged and heartbroken” by the killing of seven humanitarian aid workers in a strike by Israeli forces, strongly condemning the attack just hours after Israel’s top military commander acknowledged its military had made a “grave mistake.”Lt. Gen. Herzi Halevi made a rare admission of fault by Israel in the six-month-old war in the Gaza Strip as he accepted responsibility for the deaths of the aid workers.“It was a mistake that followed a misidentification, at night, during the war, in a very complex condition,” he said, adding, “It shouldn’t have happened.”General Halevi’s mea culpa was a…

Lalzawmi Frankcom’s text message was short and sweet: a heart emoji reply at 10:38 p.m. on Sunday to her friend Josh Phelps, who had sent along photos of their humanitarian work together on a reservation in South Dakota.Ms. Frankcom, an Australian known as Zomi, had a big day ahead on Monday. She and her colleagues from World Central Kitchen in Gaza were waiting for a ship to arrive at their newly built jetty so that they could unload hundreds of tons of sorely needed humanitarian aid.The team set off about 8 a.m. on Monday local time from Rafah, in southern…

Arguably, football doesn’t need anything extra to satisfy its collective sense of self-importance, but the idea that it can create new life certainly does that.You may remember a rather dramatic National League game at the end of last season when Wrexham and Notts County met in what was effectively a ‘winners promotion’ clash. In the 97th minute, Wrexham goalkeeper Ben Foster saved a penalty kick to seal the victory 3-2, leading the opponent by 3 points with a game in hand.Foster says the results of that moment of collective ecstasy have become clear nine months later: he recently recorded a…

She even made Thai peanut tofu with red peppers, broccoli and rice for one of the guys the night he came over to dump her in December 2020. He waited until after the meal to break the news.“If you’re just coming and ripping the Band-Aid off, at least have the forethought to bring takeout so I wouldn’t have to cook,” she said. “He let me make a whole meal.”“At that point, I said, ‘I’m never doing that again,’” she added.Brett Holzhauer, a financial content writer in Fort Lauderdale, Fla., said that cooking early on has been a fantastic way for…

In late 2021, Mark from San Diego and his wife were flying home on British Airways premium economy from Split, Croatia, via London and Dallas, but missed a connection. They were rebooked in economy on Virgin Atlantic and tried for two years to get reimbursed when finally, in December 2023, they were told they had agreed to the downgrade, which he denies. (It shouldn’t matter anyway, both Mr. Leff and Mr. Radchenko said.)They finally received $746 from British Airways earlier this week. But the full cost of their original round-trip itinerary (two tickets from San Diego to Ljubljana, Slovenia, and…

On the east side of San Jose, Calif., there is an abuela who seems to have more grandchildren than she can count.“A lot of people see me and they hug me,” Mardonia Galeana, 89, said in Spanish. “I don’t even know them, but sometimes they ask me for a blessing on the street and I do the best I can on their forehead.”Her likeness has been featured in a painting in the San José Museum of Art and in a mural in the city’s mission district. But it’s her online presence that has captivated the thousands of people who have…

As lawmakers in a nearby hearing room debated last month whether to support her legislation to expand Medicaid, Gov. Laura Kelly of Kansas dared the state’s Republican House speaker to hold a vote.“If he thinks he can kill it, bring it,” Ms. Kelly, a soft-spoken moderate Democrat, said in an interview in her sprawling office suite at the State Capitol in Topeka.The next morning, in his own office off the House floor, Speaker Dan Hawkins showed no sign of yielding. He described Medicaid expansion as “almost like the greatest Ponzi scheme ever devised.” The same day, a House committee voted…

Lizzo, the Grammy Award-winning singer, clarified on Tuesday that she was not quitting the music industry, days after her social media post saying “I QUIT” led some fans to speculate that she was ending her music career.In a video posted on social media, Lizzo said she was not leaving the music business and instead was quitting “giving any negative energy attention.”“What I’m not going to quit is the joy of my life, which is making music, which is connecting to people, cause I know I’m not alone,” she said in the video. “In no way shape or form am I…